The first thought a GIS Professional gets on seeing a GeoPDF map is how to USGS Topo as GeoPDF get it into GIS application. This particularly would be the case in US where USGS maps are all provided as high quality GeoPDFs and the analyst would want to derive maximum information from the maps. A good way to get the map into a GIS application would be in the form of high resolution GeoTIFF. USGS National Map suggests using Global Mapper for the purpose [ PDF ]. When a similar requirement came to me I tried the operation with trial version of Global Mapper.